Protein Details: Glutamate receptor ionotropic; NMDA 3A

Protein ID

ICDB_Pro_1619

Protein Name

Glutamate receptor ionotropic; NMDA 3A

Gene Name

Grin3a

Organism

Rattus norvegicus (Rat)

Length

1135 amino acids

AlphaFoldDB

AF-Q9R1M7-F1-model_v4.pdb

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance; low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits; plays a role in the synaptic refinement period; restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX; may reduce GIT1/ARHGEF7-regulated local activation of RAC1; hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.

Sequence

MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES

PDB Structures

2RC7 2RC8 2RC9 4KCD

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Isoform 1 and isoform 2 are expressed in olfactory bulb; frontal occipital; entorhinal and pyriform cortices; hippocampus; striatum; thalamus; cerebellum and spinal cord

DOI ID

10.1523/jneurosci.15-10-06498.1995; 10.1523/jneurosci.15-10-06509.1995; 10.1016/s0014-5793(98)01590-7; 10.1523/jneurosci.21-20-07985.2001; 10.1523/jneurosci.21-04-01228.2001; 10.1124/mol.62.5.1119; 10.1152/jn.00531.2001; 10.1073/pnas.1312211110; 10.1523/jneurosci.5183-13.2014

RefSeq

NP_001185512.1 [Q9R1M7-2]; NP_612555.1 [Q9R1M7-1]